Cerebral Spinal Fluid Sampling

The rationale for Cerebral Spinal Fluid (CSF) sampling in a research setting differs from clinical practice sampling when CSF is done for diagnostic purposes. First, the presence of biological molecules in CSF is a reflection of physiological or pathological CNS processes and as such is used as biomarkers of those processes. Second, CSF sampling is used to determine drug concentration in CSF compartment as the result of penetration of the drug across the blood brain barrier and their CNS PK profile. When the two are combined, changes in biomarkers can be used to monitor disease modification due to effects of study drugs. CRI Lifetree Salt Lake City’s expertise in sampling CSF allows assaying concentrations of the parent compound, drug metabolites and disease modifying biomarkers. Sampling can be obtained from a single lumbar puncture and from intermittent or continuous, or both sampling from an indwelling catheter for up to 96 hours.

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16000 Horizon Way, Suite 100
Mount Laurel, NJ 08054

Marlton Research Center
401 Route 73 North
30 Lake Center Executive Park, Suite 100
Marlton, NJ 08053

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111 N. 49th Street
Philadelphia, PA 19139

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3838 S 700 E Suite 202
Salt Lake City, Utah 84106

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Administrative Office
16000 Horizon Way Suite 100
Mount Laurel, NJ 08054



Marlton Research Center
401 Route 73 North
30 Lake Center Executive Park, Suite 100

Marlton, NJ 08053



Philadelphia Research Center
111 N. 49th Street
Philadelphia, PA 19139



Salt Lake City Research Center
3838 S 700 E Suite 202
Salt Lake City, Utah 84106